We tested the efficacy and permeation of four FDA-approved small-molecule chemotherapeutics - cisplatin, doxorubicin, homoharringtonine, and docetaxel on two patient-derived diffuse-midline-glioma models at sub-IC 50 drug concentrations for the BBB
However, this was not a controlled trial there was no placebo group, and the assessments were informal (patient surveys by phone)
All compounds are strictly for use by qualified researchers in controlled, non-clinical laboratory environments in compliance with applicable regulations
Klotho has pleiotropic renal protective actions, including anti-fibrosis, anti-oxidative stress, anti-inflammation, anti-apoptosis (Yuan et al., 2022), and modulation of autophagy ( Klotho is strongly expressed in the kidney and the level there is related to its functional state (Wang et al., 2018