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[DOI] [PMC free article] [PubMed] [Google Scholar] 16.Chandrasekaran A., Idelchik M.d.P.S., Melendez J.A

When activated, the mast cells in the skin release mediators (histamines, tryptase, TNF-alpha, CXCL9, etc.) that cause inflammation, flushing, itching, or burning.[ref] Related article: Rosacea, underlying causes, genetic susceptibility Dermatographism and mast cell activation syndrome: In a survey of mast cell activation syndrome, dermatographism was found in 89% of the patients.[ref] Dermatographism is when you get welts or raised red lines when you scratch your skin lightly

22q11.2DS is characterized by neuropsychiatric abnormalities, such as schizophrenia [357], attention-deficit hyperactive disorder, anxiety, depression, and ASD [358]

Regulations vary by region