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This failure is largely due to testing exclusively on cancer cell lines grown in liquid medium, a condition that predicts in vivo efficacy to anticancer drugs worse than cell culture in 3D gels [4, 5] and is far from adequately reflecting the therapeutic responsiveness of cancers within their native microenvironment [2, 3]

Similarly, the co-delivery of radiosensitizers or oxygen carriers can counteract tumor hypoxiaa key driver of radioresistanceby enhancing DNA damage selectively in malignant tissues [156]

However, DMF can also mediate pro-ferroptosis effects by GSH succinylation 55 , impairs NF-B/STAT3 signaling 56 , and potentiates oxidative cell death 57

PMID 16246122