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This isn't because 1:1 is mechanistically optimal in some provable way it's because researchers studying combinations of these compounds chose 1:1 as the default and the literature accumulated around that choice

Vitamin B12 and Diabetic Neuropathy Diabetic neuropathy is nerve pain due to diabetes

In contrast, when a healthcare provider diagnoses B12 deficiencyvia blood tests and clinical evaluationB12 injections serve a medical purpose: correcting a documented biochemical imbalance and preventing the progression of serious conditions

If you are considering these treatments, consult with a medical professional experienced in hormone therapy to determine the optimal approach for your specific needs.