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The enzyme uses glutathione as the ultimateelectron donor to regenerate the reduced form of the selenocysteine

It supports the proliferation and activity of lymphocytes, regulates cytokine production, and protects phagocytes from oxidative damage they generate during pathogen destruction

Acknowledgments This work was supported in part by the Japan Study Group of NAFLD (JSG-NAFLD, Kyoto, Japan)

These well-characterized findings show that immature red blood cells suffer ferroptosis stress from iron accumulation and oxygen during stress erythropoiesis, while ferroptosis is rarely detectable in normal red blood cells