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Melanin is a naturally occurring pigment that is produced by specialised skin cells known as melanocytes

What the model cannot tell us is whether the same effect size, or any effect, would appear in intact human tissue, or whether the systemic exposure needed to achieve it would be safe

al., Skeletal Muscle Signaling Following Whole-Body and Localized Heat Exposure in Humans, Frontiers in Physiology, VOLUME 11, 2020 Chang M, Ibaraki T, Naruse Y, Imamura Y