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Nat Rev Rheumatol (2018) 14(5):26978

549 This crosstalk ensures that when the chaperone system is overwhelmed, autophagy can step in to clear the accumulating toxic proteins

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Drug-Related Causes of Liver Damage Toxic hepatitis is caused by inflammation of the liver due to exposure to a toxic substance, such as over-consumption of prescription or over-the-counter medications, herbal medicines, or supplements