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they are responding

You will often see references to growth factors and vascular signaling, like pathways associated with tissue repair

Therefore, the consistent therapeutic effect of BPC 157 is accompanied by strongly elevated ( Egr1, Akt1, Kras, Src, Foxo, Srf, Vegfr2, Nos3, and Nos1 ) and decreased ( Nos2 and Nfkb ) gene expression, while Mapk1 is not activated (similar to Akt1 in ICVrats)

Theoretical risks of sustained angiogenic stimulation (promoting vascular supply to undetected pathological tissue) grow proportionally with the duration of use, as cumulative VEGF upregulation exceeds the controlled, injury-localized window intended by short-cycle research protocols