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Given the functional role of SLC6A14 in extending the range of amino acid uptake (including glutamine and leucine, both of which are activators of mTORC1), as well as providing substrates for SLC1A5 and SLC7A5, the molecule has attracted much attention 99,100

This is often closely intertwined with mast cell activation syndrome (MCAS), where accumulated toxins and chronic oxidative stress cause mast cells to become hyper-reactive, constantly degranulating and releasing histamine and other inflammatory mediators into the bloodstream

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