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Besides this, it is a major component of hormone replacement therapy in anti-aging clinics

doi: 10.1371/journal.ppat.1011223

Notice that GSH goes up for low estradiol values, reaches a peak and descends for high estradiol values Variation of GSH steady state depending on S In our model, we take the activation of GCL and GPX by estradiol to be 80%, which is a reasonable choice supported by the experimental and clinical data discussed above