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Further studies revealed that GLC increases melanin production in melanocytes by three pathways, 1) activating activator protein-1 (AP-1) and CRE promoter to activate p42/44 MAPK signaling, 2) activating cAMP signaling, and 3) decreasing GSK3 phosphorylation while inducing CREB phosphorylation (Lee et al., 2005)

Making it less suited for protocols targeting skin remodeling, where multi-day collagen synthesis signaling matters more than peak plasma levels

Over the last 25 years, many related enzymes have been sequenced

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