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Therefore the other ion channel(s) involved in the citric acid response (such as the acid sensing ion channels, or ASICs) could be upregulated or otherwise affected by TS more quickly than TRPV1

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"Our spouses have had to be very patient and understanding with the five of us," Steve said, "as cigarette-searching has sometime encroached on vacations and, in my case, a honeymoon 20 years ago that brought us to Jasper in Canada and then Vancouver, Victoria and Seattle." Through it all, Steve said, his mother, Patricia, has taken it in stride