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Some of these functions are significantly reduced only after adolescence, such as biosynthesis and degradation of polysaccharides, pentose phosphate pathway and TCA cycle. Therefore, also at a functional level, adolescence seems to represent a stage of transition towards an adult microbiome, where some functions have attained adult-like relative abundances whereas others are still present at the levels seen in young children

PPI therapy causes a clinically insignificant increase in the serum level of gastrin