GPs can prescribe B12 injections following appropriate investigation, which should include: Full blood count to identify macrocytic anaemia Serum B12 and folate levels to confirm deficiency (using laboratory-specific reference ranges) Methylmalonic acid and/or homocysteine when B12 results are borderline Intrinsic factor antibodies if pernicious anaemia is suspected Additional tests depending on clinical presentation (e.g., thyroid function, coeliac serology) When both B12 and folate deficiency are present, B12 should be replaced before folate to avoid precipitating subacute combined degeneration of the spinal cord
Vitamin B12 absorption and metabolism Vitamin B12 is a complex biomolecule that plays a vital part in key biochemical reactions
The list of drug targets was compiled after combining the outputs of SuperPred and SwissTargetPrediction and removing duplicates, and used as Set A, while epilepsy genes were used as Set B and oxidative stress-related genes were used as Set C
References: He L, Feng D, Guo H, Zhou Y, Li Z, Zhang K, Zhang W, Wang S, Wang Z, Hao Q, Zhang C, Gao Y, Gu J, Zhang Y, Li W, Li M