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Smoking can cause lung disease by damaging your airways and the small air sacs (alveoli) found in your lungs.1,2 Lung diseases caused by smoking include COPD, which includes emphysema and chronic bronchitis.1,2 Cigarette smoking causes most cases of lung cancer.1,2 If you have asthma, tobacco smoke can trigger an attack or make an attack worse.1,2 Smokers are 12 to 13 times more likely to die from COPD than nonsmokers

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Furthermore, via the upregulation of VEGF and FGF, nicotine activates other angiogenic signaling pathways in endothelial cells [288,289,290]

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