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Increasing NAD synthesis in muscle via nicotinamide phosphoribosyltransferase is not sufficient to promote oxidative metabolism

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Ferroptosis is characterized by the toxic accumulation of lipid peroxides at the cell membrane (Dixon et al, 2012

Therefore, the key step in the formation of pannus is angiogenesis, which provides a resupply for proliferating and migrating synovial cells and aggravates cartilage destruction and erosion (182)