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Studies have shown that saliva transplantation from patients with periodontitis can induce upregulation of IL-1 and IL-6 in the colon of recipient mice, while the immunosuppressive IL-10 is downregulated, suggesting that saliva-derived microbiota may induce gut microbiota dysbiosis and low-grade intestinal inflammation through immune imbalance ( P.g to mice resulted in significantly increased expression of IL-1, IL-6, and TNF- in adipose tissue

PDK4 is highly responsive (activated) to an increased NADH/NAD + , whereas, PDK2 is much less sensitive to this activation

Alzheimer Res

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