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At present, PD therapeutic options are mainly symptomatic, for e.g., dopamine replacement and agonists, monoamine oxidase (MAO) inhibitors, catechol-O-methyl transferase (COMT) inhibitors, anti-cholinergic drugs, and amantadine are standard symptomatic treatments for motor symptoms, however, none of these therapies either cures or prevents consistent neurodegeneration

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Heart failure