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For these patients, it is prescribed as a treatment for the reduction of excess abdominal fat and shown to decrease the visceral adipose tissue and waist circumference [2]

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How-ever, the bioavailability of IGF-1 depends heavily on multiple IGFBPs, IGFBP-rPs and an interplay between IGF-1, IGF-2, Insulin and their receptors, which complicates the interpretation of IGF-1 test results

Expert Opin Drug Discov 6:589595 Choo AY, Kim SG, Vander Heiden MG, Mahoney SJ, Vu H, Yoon S-O, Cantley LC, Blenis J (2010) Glucose addiction of TSC null cells Is caused by failed mTORC1-dependent balancing of metabolic demand with supply