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Vigorous shaking can cause shearing forces that literally break the amino acid bonds or cause the peptide to denatureunraveling it like a ball of yarn and rendering it biologically useless

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The result of cerebellar stimulation in stroke certainly argues that cerebellar stimulation can induce plasticity in regions as distant as the cerebral cortex (see section by Cooperrider and colleagues) and these changes may be dependent on specific molecular mechanisms (see section by Cheng and colleagues)