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May 2012;187(5):1645-1649

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After proteolysis, these methylarginines are released, and in their free form they exert their biological action

IGF-1 LR3 Mechanism and Receptor Competition IGF-1 LR3 is a synthetic analog of endogenous IGF-1 with two critical modifications: an arginine substitution at position 3 (the 'R3' designation) and a 13-amino-acid N-terminal extension