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Of clinical significance is the fact that two identified mutations in glucokinase, that are just proximal to the Cys371 residue, block S-nitrosylation of glucokinase and are the cause of a form of diabetes referred to as MODY-2

So less fat, more of your testosterone in men stays as testosterone and wont convert to estrogen. Over time, some men may even be able to wean off TRT under medical supervision, says Kohn

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