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Many users in these forums attribute this reaction to acute mast cell activation triggered by the peptide complex, noting that they require the concurrent, daily use of potent systemic antihistamines (such as Xyzal) simply to tolerate the basic administration of the protocol

And one of the polysaccharides, glycomannan, is linked to fibroblast stimulation + collagen synthesis

NSAID-induced toxicity and liver damage

This isnt always possible if youre dealing with a degenerative condition like arthritis, for example, but if you have bruxism, a night guard could provide relief, and long-term stress reduction could be a cure