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38 Arginine regulates the active state of the urea cycle by acting as an allosteric activator of N-acetyl glutamate synthetase (a mitochondrial enzyme that converts glutamate and acetyl CoA to N-acetyl glutamate)

Peroxisome proliferator-activated receptor gamma and retinoid X receptor ligands are potent inducers of differentiation and apoptosis in leukemias

Small molecule absorption becomes a particularly important issue for working with BBB models, as the BBB is a highly selective cell barrier, which often only allows small lipophilic molecules with a molecular weight below 400 Da to pass through a paracellular route 49,50,51 Therefore, the most interesting compounds for treating central nervous system (CNS) diseases often lie in the range of molecules readily absorbed by PDMS

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