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FDA reviewers, applying the statutory framework under 21 CFR 216.23(c), identified only one human study for BPC-157's proposed indication of ulcerative colitis: a decades-old meeting abstract that was never published as a peer-reviewed trial and that used an oral route of administration not the injectable or subcutaneous routes that wellness clinics commonly use

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Some researchers propose that extracellular NAD+ acts as a danger signal, 7 prompting enzymes to rapidly break it down into NAM, ADP-ribose, and potentially NR

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