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Acute gentamicin ototoxicity paradigm: Under anesthesia, animals are administered a single intratympanic injection of gentamicin (400 mg/ml) of a volume of 50 L

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Modern clinical research has shown that saffron supplementation (typically 2050mg per day) can improve visual acuity, retinal function, and contrast sensitivity in adults with AMD.58 These effects are attributed to compounds called crocin and crocetin, which may enhance retinal blood flow and protect photoreceptor cells from oxidative stress

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