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The role of Double Happiness cigarettes has changed as wedding traditions adapt to modern lifestyles

Smoking cessation increases levels of osteocalcin and uncarboxylated osteocalcin in human sera

This provides a solid link to TS-dependent impairment of BBB function whereas cigarette smoke extracts have been shown to act as a powerful activator of immune/inflammatory response pathways altering the integrity/function of the BBB [13, 14]