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The synergy between exogenous MOTS-c and exercise is not merely additive: because MOTS-c mimics one of the molecular consequences of high-intensity exercise (AMPK activation via AICAR accumulation), concurrent exercise training may amplify the peptide's effects on GLUT4 translocation and mitochondrial biogenesis

This 15amino acid fragment has been extensively characterized in peer-reviewed in-vitro and animal model research spanning three decades

KPV is a tripeptide (lysine-proline-valine) derived from alpha-MSH

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