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Abbreviations ADRB2/2AR: 2-Adrenergic receptor AKT/PKB: Protein kinase B cAMP: Cyclic adenosine monophosphate CREB: CAMP-response element binding protein DCT: Dopachrome tautomerase EF: Epimedii Folium ERK: Extracellular regulated protein kinases GSK3: Glycogen synthase kinase-3 beta HMVII: Human melanoma cell line HEM: Human epidermal melanocyte MAPK: Mitogen-activated protein kinase McSCs: Melanocyte stem cells MITF: Microphthalmia-associated transcription factor NRF2: Nuclear factor erythroid 2 (E2)-related factor 2 PM: Polygoni multiflori radix PKA: Protein kinase A PTU: 1-Phenyl-2-thiourea TCM: Traditional Chinese medicine TA: Transit-amplifying TPA: 12-O-tetradecanoylphorbol-13-acetate TYR: Tyrosinase TrKA: Tropomyosin receptor kinase A TRP-1: Tyrosinase-related protein 1 TRP-2: Tyrosinase-related protein 2 References Adly MA, et al

Contamination, concentration mismatch, storage issues, and unclear instructions can all increase risk

The KPV peptide benefits extend beyond inflammation to include antimicrobial activity and wound healing support

Start slow, listen to your body and follow up regularly