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Figure 1: Changes in fall latency during the rotarod test across the three different experimental groups

The extracellular matrix breakdown Beyond collagen and elastin, the extracellular matrix (ECM) contains glycosaminoglycans (GAGs), proteoglycans, and structural glycoproteins that maintain skin hydration, volume, and smooth texture

The FDA has also accepted this approach

Cutis 110(2 Suppl):1925 Richetta AG, Silvestri V, Giancristoforo S, Rizzolo P, DEpiro S, Graziano V, Mattozzi C, Navazio AS, Campoli M, DAmico C (2014) A-1012G promoter polymorphism of vitamin D receptor gene is associated with psoriasis risk and lower allele-specific expression