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Cagrilintide is a stable analogue of Amylin, a hormone co-secreted with insulin that delays gastric emptying and induces satiety via the amylin receptors in the hindbrain

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Immunoprecipitation Hepatocytes were lysed in an immunoprecipitation (IP) buffer (150 mM NaCl), 50 mM Tris-HCl, 1% Nonidet P-40, pH 7.8, and a mammalian cell-specific protease inhibitor cocktail