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It is documented that neurons express G-CSF receptors, and exogenous G-CSF promotes peripheral nerve regeneration and function significantly [56]

[DOI] [PubMed] [Google Scholar] 7.Rauchhaus M, Doehner W, Francis DP, Davos C, Kemp M, et al

It has been studied for effects on telomerase activity and longevity

At the molecular level, metformin activates the AMPK or PI3K/mammalian target of rapamycin (mTOR) signaling pathways via oxidative stress, thereby improving glucose and lipid metabolism, and it also contributes to improved endothelial function, which is associated with higher levels of high-density lipoprotein cholesterol (HDL-C)