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Mild reactions seen in oral CBD studies include the following: Digestive problems like diarrhea, nausea, vomiting, constipation, stomach pain, and bloating Fatigue Changes in appetite Headaches Weight changes (gain or loss) Skin irritation Sleep problems like insomnia Dizziness or lightheadedness Fever Less common but serious complications of oral CBD include liver stress, producing abnormal liver function test results

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Miao B, Yao H, Chen P, Song XJ (2022) Differential activation of pERK1/2 and c-Fos following injury to different regions of primary sensory neuron