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Although folic acid supplementation has been proven effective to control circulating homocysteine concentrations, homocysteine lowering has not affected the incidence of cardiovascular disease in supplementation trials

GPX4, together with other ferroptosis inhibitory pathways such as FSP1/CoQ10 and BH4/DHFR axes, maintains the cellular antioxidant state

Higher-risk groups include vegetarians, vegans, people with digestive disorders like Crohns disease or celiac disease, those whove had bariatric surgery, and long-term users of metformin or proton pump inhibitors

Studies in maize and barley also detected GGT activity in the apoplast (Masi et al., 2007