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Signaling events leading to EMT activate mesenchymal state in the cancer cells, which was associated with increased frequency of cancer stem cells (CSCs) sometimes also termed tumor-initiating cells [25]

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Thus, the coordination-unsaturated Fe in Fe-N 3 exhibits the strong adsorption and activation of O 2 , promotes the O-O cleavage of the adsorbed *OOH and generates the active *O intermediates, thereafter greatly improving the oxidase-like activity of pFeSAN