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The result is higher inner-ear concentration and longer retention of drugs compared to systemic administration, as demonstrated by the optical tracer studies

Urobilinogen is a substance formed in the intestines from the breakdown of bilirubin, which is produced when the liver processes red blood cells

To enhance the cell permeability of RT, we converted the carboxylic acid groups to acetoxymethyl (AM) esters, which are readily hydrolysed by esterases to regenerate RT inside cells