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Description

Use a perpendicular angle (90 degrees to the skin surface), insert the needle quickly with a smooth motion, and deliver the medication slowly over 510 seconds rather than rapid injection

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Estrogen suppresses this process indirectly by stimulating osteoblasts to produce osteoprotegerin (OPG), a soluble decoy receptor that binds RANKL and prevents its interaction with RANK

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doi: 10.1056/NEJMoa1012985 196

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