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While some patients report improvements in skin clarity or texture after B12 shots, these changes are usually most noticeable when a deficiency existed beforehand

The phenotypic outcome is a shift toward higher energy expenditure and improved adipose/lipid profiles without the catabolic loss of lean tissue commonly seen with severe caloric restriction

On the other hand, although a hypothetical cost-analysis study suggested a potential cost-saving role for androgen receptor splice variant 7, direct clinical evidence in LAC is still required, as its use is not routinely recommended in clinical practice guidelines, even though some evidence suggests its utility (161, 186)

All the authors contributed to the final version of the manuscript