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LDHB KD significantly decreased the PPP- derived lactate but increased glycolysis-derived lactate ( Supplementary Figure 2 ), suggesting that LDHB KD reduces PPP activity, impairs NADPH synthesis and limits the conversion of cysteine to cysteine

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In addition, Nle 1 -AngIV and these shorter fragments, facilitated hippocampal synaptic connectivity via synaptogenesis [70]

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