Download figure Open in new tab Figure 2: In vivo GSH-edited and GABA+-edited spectra acquired from the SM1 (A, E, n=97), Thal (B, F, n=29), mPFC (C, G, n=43(GSH)/41(GABA)), and SMA (D, H, n=55(GSH)/56(GABA)) regions
To evaluate the ability of molecules to interfere with aggregation of hCC while informing about cellular toxicity, cells were generated that produce and secrete WT and L68Q-hCC producing high-molecular weight complexes formed from the mutant protein
older children had higher tNAA (estimate 0.09 (0.02), p = 0.0001, t = 5.74) and lower Glx (estimate = 0.13 (0.03), p = 0.0001, t = 4.08)
Chemical surface functionalization of pSiNPs with n-octadecylsilane (H 3 Si (CH 2 ) 17 CH 3 , referred to here as C 18 ) imparts a hydrophobic character 24 to the mesopores (1015 nm), and thus were chosen for loading of erucamide (Fig