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We compared differences in nicotine bioavailability between the Test product and each Reference product as follows: (1) the P -value for the 2-sided test of Test versus Reference paired difference for the log-transformed parameter C max was assessed against a significance level of 0.0125

For nonstripped samples, the aged particles of marijuana smoke were larger overall than those of tobacco smoke with the CMDs being on average 23% (6%) and 29% (2%) larger for the aerodynamic (477 vs 389 nm) and mobility (410 vs 318 nm

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Interestingly, testosterone levels were correlated with the number of cigarettes smoked daily, suggesting a dose-dependent relationship