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10.1016/s1097-2765(00)00051-4 40 GreeneL

Increasing glutathione remains a promising therapeutic strategy to slow or prevent MCI and Alzheimer disease

This activation significantly increased the Bcl-2-associated X protein (Bax)/B-cell lymphoma 2 (Bcl-2) ratio and cysteine-aspartate protease 3 (Caspase-3) expression, inhibited GPX4 and quinone oxidoreductase 1 (NQO1) expression, increased MDA levels, and promoted apoptosis, ferroptosis, and lipid peroxidation in NSC-34 cells

Their advantages were that BBB architecture was not perturbed and that blood cell movements in capillaries generated shear stress, crucial for BBB maintenance