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A Cochrane review in 2017 looked at the duration of pain and bruising after subcutaneous heparin injection and reported that a slow injection taking 30 seconds to administer may reduce pain but there is no difference in bruising compared with a fast injection (Mohammady, 2017)

In this analysis, all cases, apart from one with insufficient information, revealed that the identified drugs were very probable, probable, or possible for causing SJS/TEN

Environ Mol Mutagen 60:668682 Shen HH, Lam KK, Cheng PY, Kung CW, Chen SY, Lin PC, Chung MT, Lee YM (2015) Alpha-lipoic acid prevents endotoxic shock and multiple organ dysfunction syndrome induced by endotoxemia in rats

The evidence is diverse and includes extensive work with laboratory animals, otherwise unexplained associations, factors associated with APAP metabolism, and limited studies in humans