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Glutathione supplementation suppresses muscle fatigue induced by prolonged exercise via improved aerobic metabolism Goutzourelas, N., et al

Gclc fl/fl mice were described previously 127 and were crossed to Mb1-Cre + expressing mice 46 to obtain the Gclc fl/fl Mb1-cre strain

Thus, CHAC1 serves a dual role: it preserves mitochondrial function by ensuring a cysteine supply under nutrient stress, but it also facilitates ferroptosis by maintaining ETC activity, highlighting its potential as a therapeutic target in cancer treatment ( 4.4 Apoptosis CHAC1 is implicated in apoptosis, particularly in the context of ER stress and UPR