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Future research should prioritize large, multicenter, rigorously designed RCTs with standardized outcomes, and efforts to publish both positive and negative findings are essential to establish a balanced evidence base
[12:42] If you add to that that the microglia also influence quinolinic acid, serotonin, dopamine, and a host of other neurochemical pathways that then influence the neuroexcitatory sympathetic response, you've got sensory overwhelm, everything in the world seems disproportionately threatening, and you're hyper-alert
Stem cell activity, the Wnt/-catenin signalling pathway, hormonal regulation, neurovascular control, extracellular matrix dynamics, the influence of the microbiota, inflammatory pathways, epigenetic regulation, and environmental factors are some of the important elements
Cancer 12:41
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