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(Source: references 1, 4 and 7.) Overview The laboratory mouse has been extensively used for biomedical research since the early 1900s.[1] Its successful and continued use in modern medicine relies on several qualities including ease of breeding and handling, short life cycles, and well-characterised genetics.[1, 2] Accordingly, this type of research is now carefully regulated and many guidelines exist to assist both beginners and experts in the field, particularly to help refine protocols and to ensure adverse experiences for the animal are minimised.[2-6] Many factors should be considered when administering substances to mice