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The 2024 fusion-peptide work exists precisely because researchers recognized that native DSIPs delivery to the brain is the bottleneck, and engineered around it by fusing DSIP to a blood-brain-barrier-crossing TAT transduction domain (sequence GGGGYGRKKRRQRRR) via flexible GGGGS linkers, expressed and secreted from Pichia pastoris

Key actions include: Growth hormone secretagogues preserve or increase muscle, improve fat metabolism, and improve sleep

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Comprising a sequence of 15 precisely sequenced amino acids, it is an isolated analogue of a naturally occurring protective polypeptide discovered in human gastric juice