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Vitamin C also promotes DNA demethylation in the promoters of pluripotency genes such as Tbx3, Tcl1, and Esrrb and of the promoters of genes that encode miRNA-specific ESCs such as miR-290295 and miR-1792 clusters, as well as the DNA hydroxymethylation of the Dlk1Dio3 region ( Signaling pathways activated by vitamin C

This method allows better absorption compared to oral supplements and helps support overall skin health and wellness

A monothiol mechanism was also reported for the in vitro reduction of mammalian RNR 46 and can be also employed, although with a decreased activity, by a Grx-RNR fusion protein from Facklamia ignava 47

doi: 10.15761/GIMCI.1000170