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The occurrence of endothelial dysfunction disrupts the mechanism of vascular homeostasis, resulting in blood vessels vasoconstriction, thrombosis, coagulation impairment, leukocyte adhesion, platelet activation, and oxidative stress formation that leads to inflammation

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In the context of plantar fasciitis, this continuity explains why issues in the plantar fascia often relate to dysfunctions in other areas, such as the hips, pelvis, or lower back