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In addition, researchers noted that treatment with GH and IGF-1 increases bone mineral density (BMD) in adults, and helps to optimize peak bone acquisition in patients, while also reducing risk of fracture due to GH deficiency [13]

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Desmots F, Rissel M, Gilot D et al (2002) Pro-inflammatory cytokines tumor necrosis factor and interleukin-6 and survival factor epidermal growth factor positively regulate the murine GSTA4 enzyme in hepatocytes